Steroid RU 486 inducible myogenesis by 10T1/2 fibroblastic mouse cells

Reversal of multidrug resistance by RU 486.

P-Glycoproteins represent a family of drug efflux proteins that convey multidrug resistance to cells in which they are expressed. This phenomenon can lower the efficacy of drugs used in chemotherapy. The steroid progesterone has been shown to bind P-glycoproteins and inhibit their drug efflux. We report that the antiprogestin RU 486 can reverse multidrug resistance in cells overexpressing the m...

Regulation of Cre recombinase activity by the synthetic steroid RU 486.

To create a strategy for inducible gene targeting we developed a Cre-lox recombination system which responds to the synthetic steroid RU 486. Several fusions between Cre recombinase and the hormone binding domain (HBD) of a mutated human progesterone receptor, which binds RU 486 but not progesterone, were constructed. When tested in transient expression assays recombination activities of all fu...

Mifepristone (RU 486) in Cushing's syndrome.

CONTEXT Mifepristone (RU 486) blocks the action of cortisol by binding to the glucocorticoid receptor and, therefore, is of potential therapeutic value in Cushing's syndrome. However, research in endogenous hypercortisolism has been hampered by the controversy related to the use of mifepristone for inducing abortion. Currently, new studies are planned to better define the role of RU 486 in Cush...

RU 486: the politics of choice.

Mifepristone (ru-486) and Its Analogues

Mifepristone (RU-486) is the first antiprogesterone drug used for the termination of early pregnancies (6 to 8 weeks pregnancies), a steroid synthesized in the laboratory. It has higher affinity for the progesterone receptor. It also has other potential applications as anticancer and glucocorticoid antagonist. It is desirable to increase its antiprogestational potency and eliminate the antigluc...